Phototherapy – Brain Anti Aging Cleansing Surgery
Recently, Academician Luo Qingming and Professor Zhou Feifan’s team from Hainan University published research results in the classic journal Nature, revealing the secret of “washing and anti-aging”. The brain accumulates too much dirt during the aging process, and it’s better to take the initiative to deal with cognitive decline without letting it go! Come on, follow the rhythm of the red light, your lymph nodes are healthy, your brain is clean, and your cognition is back to a youthful level! Firstly, let’s recreate this’ anti-aging brainwashing technique ‘on site. Important participants appeared one by one, they were: the faint red light? ——808nm non-invasive transcranial light. Is there a surge of heat in the brain? ——That’s cerebrospinal fluid shuttling through the brain. Researchers used cerebrospinal fluid tracer OVA-A647 to track cerebrospinal fluid and found that it travels around the brain before eventually flowing to deep cervical lymph nodes and leaving the brain; Anti aging cleansing technique? ——Behavioral tests showed that elderly mice exposed to red light achieved cognitive levels comparable to young mice! Because young mice are significantly more energetic, relaxed, have better memory, and are more likely to be interested in and explore new things, researchers conducted four behavioral tests, namely open field (OF), new object localization (NOL), new object recognition (NOR), and Y-maze test, to test the cognitive level of elderly mice. The recognition and spatial memory abilities have significantly improved, returning to a youthful level. As expected, artificial senile dementia mice also experienced similar cognitive improvements. They even found more intuitive evidence of cognitive improvement: A β protein (β – amyloid), the main trigger of Alzheimer’s disease, was significantly reduced, abnormal microglial activation representing neuroYAN was weakened, neuronal damage and synaptic loss were alleviated, and neuronal cells were greatly improved. There is also considerable evidence of neurological improvement at the genetic level: changes in gene sets involved in ion transport, cell migration, neurogenesis, and development, transcriptional changes in signaling pathways such as PI3K-AKT, TGF – β, and oxytocin related to neuronal survival, differentiation, and progression of Alzheimer’s disease, and significant downregulation of gene sets related to cell apoptosis, coagulation, hypoxia, and YAN disease response. Red light can clear A β protein, protect neurons, and demonstrate this in gene expression. Under the induction of near-infrared light, this “anti-aging cleansing technique” successfully cleans and repairs the brain, improving cognitive levels and abilities. Does the action of cerebrospinal fluid in the brain mediate the clearance of the brain and the improvement of cognitive decline? In a sensational Science paper published a few years ago, we may have found some clues: this study emphasized the important role of sleep in maintaining human cognitive function. At that time, researchers discovered a coherent model of electrophysiological fluctuations, hemodynamics, and cerebrospinal fluid dynamics during non rapid eye movement sleep (i.e., slow wave sleep or “no dream phase”)
Formula. Unlike blood confined in blood vessels, the cerebrospinal fluid pulse energy that occurs every 20 seconds during sleep directly comes into intimate contact with the brain parenchyma and washes away the A β protein in the brain through this contact. Because A β protein is one of the main causes of Alzheimer’s disease, this precisely explains the maintenance of sleep on the brain and cognition. The immune system of the brain, as one of the most delicate structures and organs in the human body, has long been believed to be disconnected from the immune system of the body. The existence of the blood-brain barrier makes the brain tightly guard against things from the blood, but the rediscovery of the dura mater lymphatic vessels in 2015 shattered this view. By connecting with deep cervical lymph nodes, meningeal lymphatic vessels successfully cross the blood-brain barrier, providing an immune bridge between the brain and the body. Afterwards, there was a major outbreak of immune discovery in the brain and the discovery of the complete process of cerebrospinal fluid circulation: as the arteries pulsated, cerebrospinal fluid in the subarachnoid space entered the deep part of the brain parenchyma along the periarterial space, and was rapidly transported by AQP4 distributed on the terminal foot of astrocytes to enter the brain parenchyma. It then flowed back through the periarterial space of the veins and finally merged into the dura mater lymphatic vessels, thus being excreted from the brain. This not only explains the principle of sleep improving cognition, but also finds the correct incision for the role of red light: cerebrospinal fluid “cleaning” is not just about washing, there must be a suitable way to export these “washing liquids” rich in A β protein, so that the brain can be truly clean. Red light is mainly responsible for maintaining the lymphatic vessels that export cerebrospinal fluid. In this study, in addition to cognitive improvement, researchers also found the effects of red light on lymphatic vessels and endothelial cells that make up lymphatic vessels. As age increases and neurological disorders progress, the lymphatic endothelial cells that make up the lymphatic vessels in the brain gradually become damaged. The morphology and functional structure of mitochondria responsible for energy metabolism inside the cells change, and the endothelial cells that should be tightly and neatly arranged outside the cells become loose. The lymphatic vessels can no longer effectively drain cerebrospinal fluid. Compared with young healthy controls, the endothelial cells in the elderly dementia group are loosely arranged and have defects in mitochondrial morphology. Under the action of red light, mitochondrial damage in lymphatic endothelial cells is repaired, the production of mitochondrial superoxide is reduced, membrane potential shows an increasing trend, and its mediated energy metabolism gradually returns to normal. The cells that make up lymphatic vessels are in a young state and naturally need to start working. The researchers examined the gene expression of these cells, and found that in addition to increased mitochondrial related gene expression such as cytochrome c oxidase activity and assembly, respiratory electron transfer, and adenosine triphosphate synthesis, there was also upregulation of gene expression related to cell proliferation, adhesion, differentiation, development, and homeostasis. Among them, the more prominent ones are the upregulation of key proteins involved in the assembly of double cell tight junctions and cell adhesion, directly pointing to the positive regulation of light on the formation of meningeal lymphatic vessels involved in intercellular tight junctions. From organelle repair to cell repair to lymphatic vessel repair, with a well-developed brain lymphatic system, the washed down A β protein can smoothly leave the brain
The brain completes the final step of brain cleansing. On the contrary, if lymphatic vessels in the brain of mice are artificially eliminated by external forces, whether in elderly mice or in mice with dementia, the cognitive anti-aging effect of red light will no longer be effective, brain neurons will no longer be repaired, and the accumulated A β protein content cannot be truly reduced. After ablating the lymphatic system of the brain, the anti-aging effect of red light is completely eliminated. With the joint efforts of relevant research in the past decade, the anti cognitive decline and improvement effects of red light have been fully explained: red light improves mitochondrial and energy metabolism functions → repairs the lymphatic system of the brain → quietly waits for the completion of cerebrospinal fluid “cleaning” → orderly guides the washing solution containing “dirty things” to leave the brain → brain repair and cognitive improvement. The longer the wavelength of light, the stronger its penetration ability. Therefore, the 808nm near-infrared light used in this article is undoubtedly a leader in “bone penetration”. A study has found through quantitative examination of human skull light penetration that 808 nm light can penetrate the scalp, skull, meninges, and brain, with a depth of about 40 millimeters, ultimately reaching the inner layer of the dura mater, which can radiate to the lymphatic system. This study also mentioned its 25% penetration rate. At the same time, the researchers also stated that although 808nm near-infrared light was used in this article, if you want the light to reach deeper parts of the brain, you can appropriately increase the wavelength of red light. 810-830nm has deeper penetration and better cognitive regulation effects; In addition, it is also possible to select weaker areas on the skull for lighting to enhance the effect, choose thinner pterygoids and frontal lobes, and abandon thicker parietal and occipital bones. Moreover, in addition to improving cognitive decline by enhancing mitochondrial function of lymphatic endothelial cells, red light has also been shown to achieve more primary or auxiliary effects: exposure to red light in newborns and young people can improve intraventricular hemorrhage, nasal near-infrared light stimulation can regulate nervous system activity, and ocular red light irradiation can alleviate myopia
Maintaining neurons and demonstrating this in gene expression, the so-called “anti-aging cleansing method” uses near-infrared light guidance to smoothly clean and repair the brain, thereby enhancing cognitive function and ability. Is it the role of cerebrospinal fluid in the brain that promotes the clearance process and improves cognitive decline? In a Science journal paper that received widespread attention a few years ago, we may have found some clues: the study emphasized the crucial role of sleep in maintaining human cognitive function. Researchers have found that there is a coordinated pattern between electrophysiological fluctuations, hemodynamics, and cerebrospinal fluid dynamics during non rapid eye movement sleep (i.e., slow wave sleep or “no dream phase”). Unlike blood being confined to blood vessels, cerebrospinal fluid experiences pulsations every 20 seconds during sleep
Being able to have direct intimate contact with the brain parenchyma and clear the A β protein in the brain through this contact. Due to the fact that A β protein is one of the main causes of Alzheimer’s disease, this precisely explains the importance of sleep in maintaining the brain and cognition. For a long time, people have believed that the immune systems of the brain and body are not interconnected. The existence of the blood-brain barrier makes the brain highly guarded against substances from the blood, but the rediscovery of the dura mater lymphatic vessels in 2015 overturned this view. By connecting with deep cervical lymph nodes, meningeal lymphatic vessels successfully cross the blood-brain barrier, building an immune bridge between the brain and the body. Subsequently, the discovery of the brain immune system and the revelation of the complete process of cerebrospinal fluid circulation followed one after another: with arterial pulsation, cerebrospinal fluid in the subarachnoid space enters the deep part of the brain parenchyma along the periarterial space, rapidly transports water through AQP4 on the terminal foot of astrocytes, quickly enters the brain parenchyma, and then flows back through the periarterial space of veins, finally merging into the dura mater lymphatic vessels and excreted from the brain. This not only explains the principle of sleep improving cognition, but also finds the correct entry point for the role of red light: cerebrospinal fluid “cleaning” is not only about cleaning, but also requires a suitable way to export these “washing liquids” rich in A β protein, so that the brain can truly be cleaned. Red light is mainly responsible for maintaining the lymphatic vessels that export cerebrospinal fluid. In this study, in addition to cognitive improvement, researchers also found the effects of red light on lymphatic vessels and endothelial cells that make up lymphatic vessels. As age increases and neurodegenerative diseases develop, the lymphatic endothelial cells that make up the lymphatic vessels in the brain gradually become damaged. The morphology and function of mitochondria responsible for energy metabolism inside the cells change, and the endothelial cells that should be tightly and neatly arranged outside the cells become loose. The lymphatic vessels can no longer effectively drain cerebrospinal fluid. Compared with the young healthy control group, the endothelial cells in the elderly dementia group are loosely arranged and have defects in mitochondrial morphology. Under the action of red light, mitochondrial damage in lymphatic endothelial cells is repaired, the production of mitochondrial superoxide decreases, membrane potential shows an increasing trend, and its mediated energy metabolism gradually normalizes. The cells that make up lymphatic vessels regain their youthful state and naturally begin to function. The researchers examined the gene expression of these cells, and found that in addition to increased expression of mitochondrial related genes such as cytochrome c oxidase activity and assembly, respiratory electron transfer, adenosine triphosphate synthesis, there was also upregulation of gene expression related to cell proliferation, adhesion, differentiation, development, and homeostasis. Among them, the upregulation of key proteins involved in the assembly of double cell tight junctions and cell adhesion is particularly significant, which directly points to the positive regulation of light on the formation of meningeal lymphatic vessels involved in intercellular tight junctions. From organelle repair to cell repair and then to lymphatic vessel repair, with a well-developed brain lymphatic system, the washed down A β protein can smoothly leave the brain and complete the final step of brain cleaning. On the contrary, if lymphatic vessels in the brains of mice are artificially eliminated by external forces, whether in the bodies of elderly mice or dementia mice
Internally, the cognitive anti-aging effect of red light will no longer be exerted, brain neurons will no longer be repaired, and the accumulated A β protein content cannot be truly reduced. After ablating the lymphatic system of the brain, the anti-aging effect brought by red light completely disappears. Therefore, with the joint efforts of relevant research in the past decade, the anti cognitive decline and improvement effects of red light have been fully explained: red light improves mitochondrial and energy metabolism functions → repairs the brain lymphatic system → quietly waits for the completion of cerebrospinal fluid “cleaning” → orderly guides the washing solution containing “dirt” to leave the brain → brain repair and cognitive improvement. The longer the wavelength of light, the stronger its penetration ability. The 808nm near-infrared light used in this article is undoubtedly a leader in “bone penetration”. A study has found through quantitative examination of human skull light penetration that 808 nm light can penetrate the scalp, skull, meninges, and brain, with a depth of about 40 millimeters, ultimately reaching the inner layer of the dura mater, which can radiate to the lymphatic system. This study also mentioned its 25% penetration rate. At the same time, the researchers pointed out that although 808nm near-infrared light was used in this article, if you want the light to reach deeper parts of the brain, you can also increase the wavelength of red light appropriately. 810-830nm has deeper penetration and better cognitive regulation effect; In addition, it is also possible to choose weaker areas on the skull for lighting to enhance the effect, choose thinner pterygoids and frontal lobes, and give up thicker parietal and occipital bones. In addition, in addition to improving cognitive decline by enhancing mitochondrial function of lymphatic endothelial cells, red light has also been shown to achieve more primary or auxiliary effects: exposure to red light in newborns and young people can improve intraventricular hemorrhage, nasal near-infrared light stimulation can regulate nervous system activity, and ocular red light irradiation can alleviate myopia